Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds. Biochem Pharmacol. Gasiewicz T A, Rucci G. Alpha-naphthoflavone acts as an antagonist of 2,3,7,8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor. Mol Pharmacol. Characterization of polyclonal antibodies to the aromatic hydrocarbon receptor.
Can J Physiol Pharmacol. Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo- p -dioxin-inducible cytochrome P 1 and P 2 genes.
Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P 1 gene. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
A new technique for the assay of infectivity of human adenovirus 5 DNA. Mutations affecting the regulation of transcription of the cytochrome P 1 gene in the mouse Hepa-1 cell line. Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways.
Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Tubulogenesis in Drosophila : a requirement for the trachealess gene product. Genes Dev. Product of the per locus of Drosophila shares homology with proteoglycan. Potent transactivation domain of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini.
Infection of human and simian tissue cultures with Rous sarcoma virus. Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P 1 via cDNA expression in yeast. EMBO J. A class of strong inhibitors of microsomal monooxygenases: the ellipticines. Chem Biol Interact. The period gene encodes a predominantly nuclear protein in adult Drosophila.
J Neurosci. Ma Q, Whitlock J P. Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function. A factor binding to the xenobiotic responsive element XRE of Pa1 gene consists of at least two helix-loop-helix proteins, Ah receptor and arnt.
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. The mechanism of action of a-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Arch Biochem Biophys. Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Nebert D W. Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions.
Mol Endocrinol. P genes: structure, evolution, and regulation. Annu Rev Biochem. Int J Biochem. Role of the Ah receptor and dioxin inducible [ Ah ] gene battery in toxicity, cancer, and signal transduction. Ann NY Acad Sci. Regulation of mouse Cyp1a-1 gene expression by dioxin: requirement of two cis -acting elements during induction. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P 1 by 3-methylcholanthrene.
Evidence that murine preimplantation embryos express aryl hydrocarbon receptor. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo- p -dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. Poland A, Knutson J C. Annu Rev Pharmacol Toxicol. Analysis of the four alleles of the murine aryl hydrocarbon receptor.
Pollenz R S. The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and non-hepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo- p -dioxin. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon dioxin receptor action.
Dioxin induces expression of c- fos and c- jun proto-oncogenes and a large increase in transcription factor AP DNA Cell Biol. The murine Cyp1a-1 gene negatively autoregulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery.
The period clock locus of D. Identification of the Ah receptor nuclear translocator protein Arnt as a component of the DNA binding form of the Ah receptor. Autoregulation plus positive and negative elements controlling transcription of the genes in the [Ah] battery. Chem Scr. Cloning, sequence determination, and tissue expression. Teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a complex environmental mixture from the Love Canal.
Fundam Appl Toxicol. Characterization of the activated form of the aryl hydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand. Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O 2 tension. Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor.
Exp Cell Res. Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor. Agonistic and antagonistic effects of alpha-naphthoflavone on dioxin receptor function. Role of the basic region helix-loop-helix dioxin receptor partner factor Arnt. Full text links Read article at publisher's site DOI : Smart citations by scite.
The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Explore citation contexts and check if this article has been supported or disputed. The aryl hydrocarbon receptor as a model PAS sensor. Cyproterone acetate acts as a disruptor of the aryl hydrocarbon receptor. Regulation of Astrocyte Functions in Multiple Sclerosis.
Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB in human skin and liver-derived cell lines. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon Ah receptor but fails to repress Ah receptor-dependent gene expression.
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells. Induction of CYP1A1. Funding Funders who supported this work.
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Search syntax reference. Contact us Helpdesk. Tech blog. Because B cells seem to be directly affected by AhR ligands in animal models, it was postulated that the AhR is predominantly expressed in activated human B cells and that it may contribute to cell growth regulation. To begin to address these issues and to extend detailed analyses of AhR function to a human system, AhR expression in resting and activated human B cells was studied.
In addition, the response of activated B cells to an environmental AhR ligand was investigated to provide insight into a possible physiological role for the AhR. Developmental expression of two members of a new class of transcription factors.
Dev Dyn. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. Toxicol Appl Pharmacol. Expression of liver phenotypes in cultured mouse hepatoma cells: synthesis and secretion of serum albumin. Dev Biol. Birnbaum L S. Endocrine effects of prenatal exposure to PCBs, dioxins, and other xenobiotics: implications for policy and future research.
Environ Health Perspect. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Dioxin-dependent activation of murine Cyp1a-1 transcription requires protein kinase C-dependent phosphorylation.
A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. Elton, S.
Personal communication. Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem. Biochem Biophys Res Commun. Am J Epidemiol. A DNA-binding factor specific for xenobiotic-responsive elements of Pc gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.
Identification of functional domains of the aryl hydrocarbon receptor. Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds. Biochem Pharmacol. Gasiewicz T A, Rucci G. Alpha-naphthoflavone acts as an antagonist of 2,3,7,8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor.
Mol Pharmacol. Characterization of polyclonal antibodies to the aromatic hydrocarbon receptor. Can J Physiol Pharmacol. Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo- p -dioxin-inducible cytochrome P 1 and P 2 genes. Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P 1 gene.
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. A new technique for the assay of infectivity of human adenovirus 5 DNA. Mutations affecting the regulation of transcription of the cytochrome P 1 gene in the mouse Hepa-1 cell line.
Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Tubulogenesis in Drosophila : a requirement for the trachealess gene product. Genes Dev. Product of the per locus of Drosophila shares homology with proteoglycan.
Potent transactivation domain of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. Infection of human and simian tissue cultures with Rous sarcoma virus. Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P 1 via cDNA expression in yeast.
EMBO J. A class of strong inhibitors of microsomal monooxygenases: the ellipticines. Chem Biol Interact. The period gene encodes a predominantly nuclear protein in adult Drosophila.
J Neurosci. Ma Q, Whitlock J P. Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function. A factor binding to the xenobiotic responsive element XRE of Pa1 gene consists of at least two helix-loop-helix proteins, Ah receptor and arnt.
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. The mechanism of action of a-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Arch Biochem Biophys. Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Nebert D W. Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions.
Mol Endocrinol. P genes: structure, evolution, and regulation. Annu Rev Biochem. Int J Biochem. Role of the Ah receptor and dioxin inducible [ Ah ] gene battery in toxicity, cancer, and signal transduction. Ann NY Acad Sci. Regulation of mouse Cyp1a-1 gene expression by dioxin: requirement of two cis -acting elements during induction. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P 1 by 3-methylcholanthrene.
Evidence that murine preimplantation embryos express aryl hydrocarbon receptor. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo- p -dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. Poland A, Knutson J C. Annu Rev Pharmacol Toxicol.
Analysis of the four alleles of the murine aryl hydrocarbon receptor. Pollenz R S. The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and non-hepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo- p -dioxin.
Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon dioxin receptor action. Dioxin induces expression of c- fos and c- jun proto-oncogenes and a large increase in transcription factor AP DNA Cell Biol.
The murine Cyp1a-1 gene negatively autoregulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery. The period clock locus of D.
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